Matthias Lutolf, 3rd Call 2011
EPFL
Laboratory of Stem Cell Bioengineering, Institute of Bioengineering
matthias.lutolf@epfl.ch
+41 21 693 18 76

Nick Barker, 2nd Call 2010
University of Edinburgh & Institute for Medical Biology, Singapore
MRC Centre for Regenerative Medicine

Dr. Adam Giangreco has expertise identifying and characterising endogenous pulmonary stem cells, with particular interests in lung regeneration, ageing, and carcinogenesis.  He has recently developed techniques to allow in vivo assessment of lung stem cell function (Giangreco, et al. PNAS June 2009), and he is currently determining the key signalling pathways that mediate lung stem cell growth, quiescence and differentiation.  Adam is funded by a European Research Council Starting Investigator Award.

Niels Geijsen, PhD is a principal investigator at the Hubrecht Institute in Utrecht, The Netherlands and a Professor of Regenerative Medicine and the Utrecht University Veterinary School. He has expertise in (induced) pluripotent stem cells and early mammalian germline stem cells. His group focuses on exploring the mechanisms by which growth factor signals in the stem cell environment modulate the pluripotent stem cell's functional properties.

Rossella Galli, 1st Call 2009
San Rafaelle Scientific Institute, Milan
Division of Regenerative Medicine, Stem Cells and Gene Therapy
galli.rossella@hsr.it
+39 (0)2 26434626

Helena Mira, 1st Call 2009
Carlos III Health Institute
Department of Cell Biology and Development
hmira@isciii.es
+34 918223271

Stanimir Kyurkchiev, 1st Call 2009
Institute of Biology and Immunology of Reproduction
Department of Molecular Immunology
kyurkch@hotmail.com

We are interested in genetic programs of neural stem cells (NSC) in brain development and postnatal neurogenesis, and in how NSC misregulation can lead to pathology (hereditary disease, cancer stem cells). By generating mice and NSCs mutated in the Sox2 transcription factor (active in many stem cell types), we are beginning to understand Sox2 functions and molecular targets in neural cells (Favaro et al., Nat.Neurosci. 2009),  and to address Sox2 chromatin-organizing roles by genome-wide functional genomics.

Ignacio Flores, 2nd Call 2010
Spanish National Cardiovascular Investigation Centre
Cardiovascular Developmental Biology
iflores@cnic.es
+34-914531200

Dr. Rossella Galli has a long-standing experience in the field of neural stem cells (NSCs). Currently, her research interest is focused on the functional characterization of cell-autonomous molecular determinants, known to control cardinal stem cell properties in normal NSCs, in the attempt of understanding their putative role in regulating the same properties in brain tumor-derived cancer stem cells.

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Dr. Hiiragi is an ERC Research Group Leader at the MPI in Muenster. His laboratory studies early mouse development as a model system to understand molecular mechanisms leading to establishment of pluripotency in vivo. His laboratory has established live-embryo imaging and identified dynamic heterogeneity during embryonic patterning. Current projects are aimed at systems-level understanding of principles in early mammalian development.

Raymond Poot, 1st Call 2009
Erasmus Medical Center
Department of Cell Biology
r.poot@erasmusmc.nl
+31 (0) 10 7043352

Dr Astrid Limb’s expertise focuses on investigations into overcoming natural barriers for retinal stem cell transplantation, to create a permissive environment in which grafted cells could functionally integrate. Her research involves identification, expansion and neural differentiation of adult Müller stem cells from the human neural retina, as well as transplantation of these cells into experimental models of retinal degeneration and assessment of retinal function.

Dr. Giuseppe Testa has expertise in the fields of genome engineering, stem cells and chromatin regulation, in which he pioneered new DNA engineering technologies and the characterization of new histone modifiers. His research theme is the epigenetics of lineage commitment and maintenance. His lab studies the function of histone lysine methylation in three related aspects of genome regulation: i) the physiology of genome programming during neural differentiation; ii) the aberrant genome programming in cancer; and iii) the induced genome reprogramming that enables cell fate reassignment.

Eiva Bernotiene, 1st Call 2009
State Research Institute
The Centre of Innovative Medicine
eiva.bernotiene@ekmi.vu.lt
(+370) 614 61008

We use mammalian skeletal myogenesis as a powerful system with which to study the molecular regulation of genesis, activation, proliferation and differentiation of stem cells during adult muscle regeneration and growth. Our ultimate objective is to understand the molecular mechanisms underlying muscle fiber degeneration and loss of muscle mass occurring in neuromuscular disorders and during aging.

Dr Véronique Azuara has worked for several years in the field of developmental biology and genetics moving from lymphocyte development (PhD training at the Pasteur Institute – Paris) to epigenetic studies (post-doctoral training at the MRC/Clinical Sciences Centre – London) to explore how chromatin shut down contributes to lineage restriction and maintenance of cell fate identity through development. Since being at the Institute of Reproductive and Developmental Biology (Imperial College London), her group has focused on understanding how potency and differentiation are critically balanced in stem cells and in the early embryo

Dr. Jens Schwamborn is a junior group leader at the University Münster. His research interests are in the field of mammalian neural stem cells, reprogramming technology and adult neurogenesis. He is particularly interested in the mechanisms and molecules that regulate neural stem cell maintenance, cell fate programming and neural stem cell replacement therapies.

Zsuzsanna Izsvák, 2nd Call 2010
Max-Delbrück Centre for Molecular Medicine
Mobile DNA
zizsvak@mdc-berlin.de
+49 30 9406 3510

Isidro Sanchez-Garcia, 1st Call 2009
Spanish Research Council (CSIC)
Instituto de Biologia Molecular y Celular del Cancer (IBMCC)
isg@usal.es
+34-923-238403

Adam Giangreco, 2nd Call 2010
University College London
Internal Medicine
a.giangreco@ucl.ac.uk
020 76796926

Dr. Garcia-Perez has expertise in the field of human embryonic stem cells, human embryonic carcinoma cells, induced pluripotent stem cells, and neuronal stem cells. His lab is interested in dissecting the impact of mobile DNA in the genome of stem cells, and discover mechanisms that may act to restrict LINE-1 retrotransposon mobilization.  In addition, the Garcia-Perez lab studies the impact of LINE-1 retrotransposons in somatic stem cells and in Fanconi Anemia patients.

Elly Tanaka, 1st Call 2009
Centre for Regenerative Therapies, Dresden, Germany
elly.tanaka@crt-dresden.de
+49 (0)351 272 06652

Pilar Sánchez Gómez, 1st Call 2009
Instituto de Salud Carlos III
Department of Cell Biology and Development/ Neuro-oncology Unit
psanchezg@isciii.es
+34 (0) 918223265

Cédric Blanpain, 2nd Call 2010
Université Libre de Bruxelles
Medical School
cedric.blanpain@ulb.ac.be
+3225554175

Takashi Hiiragi, 2nd Call 2010
Max Planck institute for Molecular Biomedicine
Mammalian Development Laboratory
hiiragi@mpi-muenster.mpg.de
+49 (0)251 70365 550

Dr. Isidro Sanchez-Garcia has expertise in the field of stem cells and cancer and has pioneered key advances in cancer as a reprogramming-like process.

Silvia Nicolis, 2nd Call 2010
University of Milano-Bicocca
Genetics
silvia.nicolis@unimib.it
+39 02 6448 3339

Michael Sieweke gained his PhD from UC Berkeley, working with with Mina Bissell . After a postdoc with Thomas Graf and a junior faculty position at the EMBL Heidelberg, he was recruited as research director on the associate professor level  by the French national research agency CNRS and moved to the Centre d’Immunologie de Marseille-Luminy (CIML) in Marseille, where  he has been a principle investigator since 1999 and was promoted to research director on the full professor level in 2009. He has been interested in differentiation and growth control throughout his career and is an expert on hematopoietic stem cells, macrophage differentiation, hematopoietic and Maf family transcription factors. His principal research interests are the control of cell fate decisions and self renewal in stem cells  and mature cells, stability and plasticity of the differentiated phenotype and the role of macrophages in regeneration.

Dr. Eiva Bernotiene has expertise on analysing properties of mesenchymal stromal cells (MSC) with a particular emphasize on possible application in rheumatology for enhancement of regeneration potential of damaged cartilage, and suppression of autoimmune process and inflammation. Field of research includes MSC isolated from synovial fluid and tissues derived from both, healthy and arthritic joints of adult and children patients. Bernotiene also has expertise and interest in MSC from adipose tissue, placenta and umbilical cord blood and tissues and bone marrow.

Cédric Blanpain is MD, PhD and assistant professor of the Belgian FNRS at the IRIBHM, Université Libre de Bruxelles, Belgium. His lab is studying stem cells during development, homeostasis and tumor development. In particular, he is studying the cellular origin of skin cancers and the mechanisms underlying tumor initiation and growth. The ERC and the young EMBO investigator program support his research.

Niels Geijsen, 2nd Call 2010
Netherlands Institute for Developmental Biology
Hubrecht Institute
n.geijsen@hubrecht.eu
+31-30-2121800

Cédric Blanpain is MD, PhD and assistant professor of the Belgian FNRS at the IRIBHM, Université Libre de Bruxelles, Belgium. His lab is studying stem cells during development, homeostasis and tumor development. In particular, he is studying the cellular origin of skin cancers and the mechanisms underlying tumor initiation and growth. The ERC and the young EMBO investigator program support his research.

As a cellular biologist Dr. Pilar Sanchez Gomez has been interested in the molecular mechanisms that control adult neural stem cell (NSC) behavior. Her work has contributed to establish the role of Shh, PEDF and DYRK1A, in the Subventricular Zone niche in the mouse. Now her lab is particularly focused in describing the similarities and differences between the regulation of NSCs and brain tumor initiating cells. She is exploring new therapeutic avenues for the aggressive forms of this type of cancer. 

Dr. Raymond Poot’s lab has expertise in protein purification and ChIP analysis of key transcription factors in embryonic and neural stem cells. His interest lies in defining the transcription factor networks that control the self renewal and differentiation of embryonic and neural stem cells and their relation to human disease.

Petr Svoboda is a junior group leader at the Institute of Molecular Genetics AS CR in Prague since 2007. He studies post-transcriptional regulations during oocyte-to-zygote transition and the role of small RNAs in embryonic stem cells. He received Ph.D at the University of Pennsylvania where he studied RNA interference in mouse oocytes in Richard Schultz group. During his postdoc in Witold Filipowicz group at the FMI in Basel, he studied RNA silencing in mammalian cells.

Dr. Manzanares is a senior scientist at the CNIC in Madrid, where his research group is studying the evolution of embryonic pluripotency in vertebrates. He is also interested in understanding the transcriptional regulation of lineage choice between different stem cell populations that occurs in the blastocyst. To achieve these goals, his group uses a variety of organisms and experimental approaches, including mouse transgenesis, ES and TS cell culture, chick embryology, and comparative genomics.

Bill Keyes PhD is a Group Leader in the Differentiation and Cancer Program at the Centre for Genomic Regulation (CRG) in Barcelona. his lab is interested in studying common mechanisms that link the processes of cancer and aging. In particular, they are focused on studying the functional role and molecular mechanisms of cellular senescence in both of these events, and how a deregulation of normal epithelial stem cell proliferation is involved.

Nick Barker is a principle investigator at the IMB in Singapore and visiting Professor at the CRM in Edinburgh. He has expertise in the identification and functional characterization of adult stem cells.  He employs mouse models to facilitate in-vivo lineage tracing from candidate stem cell populations and to assess their contribution to cancer initiation and progression. His ultimate aim is to harness the regenerative capacity of these adult stem cells for therapeutic use.

Associate Principle Investigators

Lino Ferreira, 1st Call 2009
Center of Neurosciences and Cell Biology , University of Coimbra, Portugal
Biomaterials and Stem Cell-based Therapeutics
lino@biocant.pt
+351- 231 419 040

Dr. Ignacio Flores is a junior group leader at the Spanish National Center for Cardiovascular Research (CNIC) in Madrid. He is interested in the role of telomeres and telomerase in stem cells during organ regeneration and aging.  His lab is presently using model organisms with different regeneration capacities, such as planarian, zebrafish and mice to assess the implication of telomere reserves and telomerase in tissue replacement.

Cédric Maurange, 2nd Call 2010
Institute of Developmental Biology of Marseille-Luminy
Neural stem cell plasticity in Drosophila
cedric.maurange@univ-amu.fr
+33 (0) 491 269 606

Miguel Manzanares, 1st Call 2009
CNIC-Centro Nacional de Investigaciones Cardiovasculares
mmanzanares@cnic.es
+34 91 4531311

Véronique Azuara, 2nd Call 2010
Imperial College London
Epigenetics and Development Group
v.azuara@imperial.ac.uk
00 44 (0)20 7594 1915

Jose Luís García-Pérez, 2nd Call 2010
Pfizer-University of Granada
Junta de Andalucía Centre for Genomics and Oncological Research (GENYO)
+34 958 637 082

Eran Meshorer is heading the ‘Stem Cell Chromatin’ lab, where he studies chromatin plasticity and epigenetic regulation in embryonic stem (ES) cells, ES cell neuronal differentiation and primary neurons. In parallel, Eran’s lab also studies chromatin regulation in reprogramming of somatic cells into induced pluripotent stem (iPS) cells, both in mouse, as a basic research tool, and in human, mostly in poly-glutamine-related neurodegenerative diseases, including Huntington disease (HD) and Machado Joseph disease (MJD).

Maria Anna Ciemerych began her research with studies focusing at the cell cycle regulation of mouse oocytes and preimplantation embryos (Ph.D. at the University of Warsaw), then investigated the role of the cell cycle regulators- D-type cyclins, in mouse development (Dana Farber Cancer Institute, Harvard Medical School) . Currently, back at the University of warsaw, she heads the Department of Cytology which investigates the potential of various stem cells to differentiate into myoblasts and to participate in the regeneration of skeletal muscle.

Dr Annette Meeson has expertise in the identification and characterisation of adult stem cells, and is involved in optimising isolation techniques for stem cells from both normal, injured and diseased tissue. Her expertise includes isolation of stem cells from multiple organs as well as from solid tumours and fluid aspirates associated with breast and ovarian tumours. Her research interests are focused on two main areas (1) the contribution of stem cells to breast and ovarian cancer progression. (2) Stem cells of cardiac and extra-cardiac origin to treat cardiomyopathy.

Lukas Sommer, 1st Call 2009
University of Zurich
Institute of Anatomy, Division of Cell and Developmental Biology
lukas.sommer@anatom.uzh.ch
+41 (0)44 635 53 50

Jens Christian Schwamborn, 1st Call 2009
University Münster
Medical Faculty, Institute for Cell Biology, Stem Cell Biology and Regeneration group
jschwamb@uni-muenster.de
+49 (0)251 8357183

Genetic approaches in mouse model systems combined with cell biological assays have allowed Professor Lukas Sommer to identify mechanisms regulating stem cell fates in the developing CNS and in neural crest-derived tissues. Our research also led to the identification and characterization of adult neural crest-derived stem cells and the study of disease mechanisms involving aberrant neural crest development and tumor formation. Professor Sommer is the current Chair of the Swiss Stem Cell Network SSCN.

Astrid Limb, 1st Call 2009
University College London
Institute of Ophthalmology
g.limb@ucl.ac.uk
+44 (0) 207 608 6974

Dr Cédric Maurange has expertise in epigenetics, regeneration and neural stem cell biology. Using Drosophila as a model organism, his aims are to identify the gene regulatory networks that modulate neural stem cell properties during the course of development.   He is also exploring their potential deregulation in cancer neural stem cells. Ultimately he hopes to comprehend how these gene networks can be manipulated for regenerative and anti-cancer purposes.

Annette Meeson, 1st Call 2009
Newcastle University
North East England Stem Cell Institute and Institute of Cellular Medicine
Annette.Meeson@ncl.ac.uk
+44 (0) 191 222 8239

Helena Mira has expertise in the field of neural stem cells. She is interested in the molecular and cellular mechanisms that regulate stem cells in the adult brain. Her current emphasis is on the aging perspective. Her lab explores both cell intrinsic and cell extrinsic (niche) contributions to the aging phenotype. In addition to addressing basic questions, her long-term research interests include the development of stem cell-based strategies for the treatment of age-related neurodegenerative disorders

Bill Keyes, 3rd Call 2011
Centre for Genomic Regulation
Differentiation and Cancer Program
bill.keyes@crg.es
+34 933 160 261

Eran Meshorer, 2nd Call 2010
The Hebrew University of Jerusalem
Institute of Life Sciences, Department of Genetics
meshorer@cc.huji.ac.il
+972-2-6585161

Maria Anna Ciemerych, 3rd Call 2011
University of Warsaw
Department of Cytology, Faculty of Biology
ciemerych@biol.uw.edu.pl
+48 22 55 42 216

Michael Sieweke, 2nd Call 2010
Centre d'Immunologie de Marseille-Luminy
sieweke@ciml.univ-mrs.fr
+33 (0) 4 91 26 94 38

Dr. Matthias Lutolf is Assistant Professor at EPFL’s Institute of Bioengineering. Research in his Laboratory of Stem Cell Bioengineering (LSCB) is at the interface of stem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem cells. This question is addressed by creating well-defined artificial niches that allow probing the biochemical stem cell-niche crosstalk at the single cell level and in high-throughput.

Petr Svoboda, 3rd Call 2011
Institute of Molecular Genetics
Department of Epigenetic Regulations
Petr.Svoboda@img.cas.cz
+420 241063147

Bo Porse, 1st Call 2009
University of Copenhagen/Copenhagen University Hospital
Biotech Research and Innovation Centre
Bo.porse@bric.ku.dk
+45 3532 5620

Professor Bo Porse is a molecular biologist interested in the mechanisms underlying normal and malignant hematopoiesis from a stem cell-centric viewpoint. His main focus areas are 1) Transcription factors in normal and malignant hematopoiesis. 2) The influence of posttranscriptional regulation of mRNA biology on stem cell functions. 3) Elucidation of differences between hematopoietic stems cells and their leukemic counterparts.

José received his first degree in Biology from the University of Porto, in Portugal. He then went on to do his PhD studies at Imperial College under the supervision of Professor Neil Brockdorff on heritable silencing mechanisms during mouse development. Following this, he moved to Professor Austin Smith's laboratory at the University of Edinburgh as an EMBO post-doctoral fellow to investigate factors involved in nuclear reprogramming. This work has led to discoveries in the field of induced pluripotency, which is his current area of research. Presently he is focusing on the molecular events and mechanisms underlying induced pluripotency.

Professor Stanimir Kyurkchiev, MD, DSc, has a long lasting experience in reproductive biology and immunology. Since 2005 his group is working on the immunomodulatory activities of human mesenchymal stem cells isolated from different sources – bone marrow, adipose tissue, endometrium, decidua. Professor Kyurkchiev’s group is currently developing a project on the controlled differentiation of human induced pluripotent stem cells into hematopoietic stem cells and lymphoid cells.

Pura Muñoz Canoves, 2nd Call 2010
Pompeu Fabra University
Experimental and Health Sciences, Cell Biology Unit
pura.munoz@upf.edu
+34 93 316 0891

José Silva, 2nd Call 2010
University of Cambridge
Wellcome Trust Centre for Stem Cell Research
jcs64@cscr.cam.ac.uk
+44 1223 760208

Professor Elly Tanaka studies regeneration using the salamander as a model system. She is interested in understanding how stem cells in regeneration systems undertake a full regeneration response, and how this capacity has been restricted in mammalian equivalents. In particular she studies spinal cord regeneration and limb regeneration

Zsuzsanna Izsvak’s laboratory was involved in inventing the Sleeping Beauty (SB) transposon system. This molecule brings a revolutionary technology platform for genetic engineering in vertebrates, including gene discovery in model species and for therapeutic transgene delivery for possible human applications. The hyperactive SB100X system can stably transfer genes to stem induced pluripotent stem (iPS) or progenitor cells. We have established a safe and efficient method of inducing transient (removable) pluripotency based upon state-of-the-art transposon-based gene delivery vectors. We are conducting a systematic survey to monitor genome stability, including transcriptional activation of endogenous retroviruses (ERVs) in the human genome following iPS reprogramming and differentiation.

Dr. Petra Hajkova is a group leader at the MRC Clinical Sciences Centre in London.
The main focus of her lab is the investigation of molecular mechanisms that lead to the erasure of epigenetic memory at both histone and DNA modification level.  Major epigenetic changes underlie the process of epigenetic reprogramming in vivo and in vitro (SCNT, iPS generation...).  Since the in vitro reprogramming systems are characterised by very low efficiency Petra’s lab focuses on the systems where epigenetic reprogramming occurs naturally as a part of normal embryonic development.

Petra Hajkova, 2nd Call 2010
MRC Clinical Sciences Centre
Reprogramming and Chromatin Group
petra.hajkova@csc.mrc.ac.uk
+44 20 8383 8264

Giuseppe Testa, 1st Call 2009
European Institute of Oncology
Experimental Oncology
giuseppe.testa@ieo.eu
+39-02-94375105