European Federation for Systematic Stem Cell Biology
EuroSyStem is an EC funded partnership between Universities, small to medium businesses (SMEs) and named researchers from both the public and private sector.
There are 20 partners in the consortium, four based in the UK and sixteen across seven other European countries. The scientific co-ordinator of the EuroSyStem project is Austin Smith of Cambridge University; Gerald de Haan of the University of Groningen is deputy co-ordinator.
The Centres involved are all international leaders in their respective fields, and collectively provide the skills and technologies necessary for ground-breaking stem cell research. There are 29 research groups involved in the project.
Our ambition is to interlink complementary biological and computational expertise so as to drive the generation of new knowledge on the characteristics of normal and abnormal stem cells.
In addition, the EuroSyStem Project has created the European Stem Cell Group, a network of leading and emerging researchers who have become Associate Principal Investigators with the project. This group will continue to be a leading force in stem cell research collaboration and networking beyond the life of the current project.
This four year project started on 1st March 2008 and will finish on 29th Febuary 2012.
The EuroSyStem Federation brings together elite European research teams to create a unique and world-leading programme in fundamental stem cell biology. Our ambition is to interlink complementary biological and computational expertise so as to drive the generation of new knowledge on the characteristics of normal and abnormal stem cells.
We concentrate on illuminating the molecular circuitry governing the decision between self-renewal and commitment to differentiation. By measuring and modelling stem cell properties and behaviour we will pave the way for application of systems methodology. We will mine and exploit information from studies and screens in model organisms, but our primary
focus is on the paradigmatic mammalian stem cell systems - haematopoiesis and epithelia in vivo, and embryonic and neural stem cells in vitro.
We will cross-evaluate between systems issues of cellular hierarchy, signalling, epigenetics, dysregulation, and plasticity.
Microenvironmental perturbation, asymmetric division, and transcriptional regulation are considered in a cross-cutting mechanism-centred work package.
Our multidisciplinary approach includes transgenesis, real time imaging, multi-parameter flow cytometry, transcriptomics, RNA interference, proteomics and single cell methodologies.
SMEs contribute to the development of enhanced resolution quantitative technologies. A platform work package will provide new computational tools and database resources, enabling implementation of novel analytical and modelling approaches. EuroSyStem will engage with and provide a focal point for the European stem cell research community. The
focussed collaborations within the EuroSyStem research project will be augmented by federating the best new independent investigators working in different tissues and organisms across Europe.
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